The best way to untangle a knotty tangle is not to “untie” the knots, but to keep pulling the loops apart wider and wider. Just make the mess as big, loose and open as possible. As you open up the knots they will unravel themselves. Works on cords, strings, hoses, yarns, or electronic cables.
The universe is asymmetric and I am persuaded that life, as it is known to us, is a direct result of the asymmetry of the universe or of its indirect consequences.